Abstract
The management of screening is very similar all over the world. The current DS screening strategies biochemistry (AFP, HCG, uE3 and inhibin A) the combine test in the first trimester (ultrasonography markers - nuchal transclucency and serum biochemistry - PAPP-A and free beta HCG), or combinations of results from the both trimesters - integrated test, which has the best efficacy (> 90%); as well as safety and cost efficiency.
For a true diagnosis, the chromosomes of the foetus must be examined. The thyroid markers - TSA, TPOAb and FT4 are used for screening of thyroid disorders.