Must the start of insulin treatment in type 2 diabetes patients be connected with increasing of their body weight?
Abstract
BACKGROUND AND AIMS: The primary objective of the extended study KILOS I (=KILOS II) was to evaluate the change in body weight and BMI during next 12 months on insulin detemir treatment and to compare it with the changes in body weight and BMI during the previous 12 months of detemir treatment following another basal insulin (NPH, glargin) treatment. The secondary objective of the study was to evaluate the changes in glycaemic control measured by HbA1c.
MATERIALS AND METHODS: This study was a 17-sites, open, not controlled, observational. Data of 168 patients with type 2 diabetes from study KILOS I were collected.
In extended study the basic data of patients were recorded next 12 month. CONCLUSION: The weight of patients increased on the average by 2,11 kg before change of basal insulin therapy to detemir in one year.
Weight decreased by 1,82 kg per year on the average after switch to detemir and still decreased durin 1 years of extended study by -0,82 kg. Mean drop in HbA1c value was -0.54% and patients hold on the same value during 1 year of extended study.