Abstract
Fatty acids (FA) belong to the family of basic biomolecules. Changes in the composition of fatty acids were described in many diseases.
The aim of pilote study was to analyze compostion of FA in plasma lipids in patients with ChP. Laboratory parameters were examined by automatic analysators.
FA patterns were analyzed in plasma lipid classes by gas-chromatography. We observed increased proportion of total monounsaturated FA (MUFA) in PC group, increased activities of n9-desaturase and 5-desaturase.
Proportion of dihomo-gama-linolenic acid (DHGLA) correlated positively with visceral protein levels and negatively with CRP level. Correlations of MUFA with these variables were opposite.
Proportions of -linolenic (ALA), DHGLA, eicosapentaenoic acid (EPA) and total polyunsaturated FAPUFA n-3 displayed negative trend with tumor staging. Contents of MUFA showed positive trend with stage of malnutrition according to nutritional risk index.
We observed increased proportion of total monounsaturated FA (MUFA), decreased proportion of PUFA n-3 and PUFA n-6 in ChP group. There was not any difference in proportion of a-linolenic acid (ALA, 18:3n-3).
We observed decreased proportion of eicosapentaenoic acid (EPA, 20:5n-3) and of docosahexaenoic acid (DHA, 22:6n-3) in ChP. The proportion of MUFA was increased in the ChP group suffering from exocrine dysfunction in comparison to the ChP group not suffering from exocrine dysfunction. exocrine.
ChP patients with exocrine dysfunction had significantly decreased concentration of PUFA n-6 in comparison to ChP patients not suffering from exocrine dysfunction. Proportion of PUFA n-3 was without significant difference between these groups.
Changes in FA profile implicated some pathophysiological mechanisms including malasorbtion of FA resulting in deficiency of essential FA responsible for disturbed FA metabolism in ChP and importance of appropriate nutritional support.