Charles Explorer logo
🇬🇧

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

Publication at Faculty of Science, Central Library of Charles University |
2013

Abstract

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.