Impact of graft loss among kidney diseases with a high risk of post-transplant recurrence in the paediatric population
Abstract
Patients with focal and segmental glomerulosclerosis (FSGS), haemolytic uraemic syndrome (HUS), membranoproliferative glomerulonephritis Type I or II (MPGN), IgA nephropathy or Henoch Schnlein Purpura (HSP/IgA) or systemic lupus erythomatosus (SLE) underwent pre-emptive transplantation significantly less often than patients with hypoplasia and/or dysplasia. The rate of living donation was lower among patients with FSGS and SLE than in patients with hypoplasia and/or dysplasia.
In comparison with hypoplasia and/or dysplasia patients with a risk of 14.4, the 5-year risk of graft loss was significantly increased in patients with FSGS (25.7) and MPGN (32.4) while it was not significantly increased in children with HUS (18.9), HSP/IgA (16.3) or SLE (20.3). One-year graft survival strongly improved among HUS patients from 17.1 in 19951999 to 3.6 in 20052009 and was not accompanied by a decrease in the number of transplantations.