Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions

Abstract

Cancerogenic and nephrotoxic aristolochic acids are activated by human cytochromes P450 1A1 and 1A: study on enzyme-aristolochic acid molecular interactions

Keywords

• aristolochic acid
• nephrotoxin
• carcinogen
• chinese herbs nephropathy
• cytochromes
• NADPH:CYP reductase
• microsomes
• DNA adducts