Phenotypic Effects of CD3[zeta] Targeting into Glycosphingolipid-Enriched Membrane Microdomains (GEMs) of T Cells

Abstract

In the present study we tested whether the forced expression of the CD3z chain within detergentresistant, glycosphingolipid-enriched membrane microdomains (GEMs) will result in a constitutively activated phenotype in human T cells. To this aim, a monomer

Keywords

• T cells
• Jurkat cells
• T cell receptor
• GEMs
• signal transduction
• tyrosine phosphorylation
• transfection