CYP1A1/2 and prostaglandin H synthase catalyze reductive activation of inflammatory drug aristolochic acid and that results in DNA adduct formation

Abstract

Aristolochic acid (AA) is implicated in Chinese herbs nephropathy. CYP1A1/2 and prostaglandin H synthase are the major enzymes involved in reductive activation of AA.

Keywords

• Stiborová Marie
• 21952333