Abstract
Some study detected abnormalities in rest brain glucose metabolism in patients with schizophrenia. These result can be done due to antipsychotic therapy or due to schizophrenia.
Methods: We assessed the group of patients with 1. episode of schizophrenia (n=10) treated with risperidon and mentally health control group (n=10) with 18FDG positron emission tomography (PET). Four patients were assessed before and after 4-6 weeks of risperidone therapy.
Image analysis was performed using Statistical Parametric Mapping 99 (SPM99). Results: SPM group analysis revealed increased 18FDG uptake in the schizophrenia patients during antipsychotic therapy or in antipsychotic naive state in cerebellum, temporal, parietal cortex and anterior cingulum.
Risperidone therapy lead to decrease 18FDG uptake in cerebellum, temporal cortex, anterior cingulum and increase in parietal cortex. Conclusions: Brain glucose abnormality in patients with schizophrenia supports hypothesis about cortico-subcortico-cerebellar dysfunction in schizophrenia.
Risperidone therapy can partially repair this dysfunction.