Potency comparison of Peptidomimetic Inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compounds

Klíčová slova

• In order to design subnanomolar inhibitors of both HIV-1 and HIV-2 proteases
• we prepared a series of compounds varying in the chemistry of the scissile bond replacement as well as in the side chains. Using this approach we were able to d