Abstract
Background: Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant.
In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). Methods: The occurrence of IHD was determined in Gilbert syndrome (GS) patients above 40 years (n = 50).
The diagnosis was based on past medical history and ECG criteria. The occurrence was related to that of the comparable general population (n = 2296).
Serum biochemistry, including the total antioxidant status was evaluated in the GS subjects. IHD patients (n = 38) and control subjects (n = 38).
Results: The prevalence of IHD in GS subjects (aged 49.7 +/- 9.0 years) was 2% (0.05-10.7%, 95% confidence interval), compared to 12.1% in a general population (P < 0.05). Bilirubin. total antioxidant capacity and high density lipoprotein (HDL) cholesterol were found to be significantly higher in GS subjects compared to control groups (P < 0.05).
According to linear discriminant analysis, hyperbilirubinemia rather than elevation of HDL cholesterol levels seemed to be more important in protection from IHD. Conclusions: In the present study, low prevalence of IHD in GS subjects was detected.
It may be presumed that chronic hyperbilirubinemia prevent the development of IHD by increasing the serum antioxidant capacity.