Publication at Second Faculty of Medicine, Third Faculty of Medicine |
2003
Abstract
Aim: To evaluate the effects of estrogen substitution on the uterine development in patients with Turner syndrome. Method: 57 women, aged 18.1-41.5 years, were treated with estrogen from puberty induction.
Results: In 21 women (37%), the uterus developed to >65 mm in length. The daily estrogen dose correlated with both uterine length (r = 0.29; p 65 mm (p < 0.05).
In 50% of the women (18 were evaluated), an adult-shaped uterus developed. Previous growth hormone therapy (n = 32) had no impact on the uterus length.
Conclusions: The uterine development was suboptimal in most patients. Further investigation is needed to optimize estrogen therapy for uterine development in patients with Turner syndrome.