Publikace na 2. lékařská fakulta |
2002
Abstrakt
We observed a case of a 48-year-old woman with recurrent depressive disorder. resistant to antidepressants and to electroconvulsive therapy, in whom the severe psychotic depression had led to repeated suicidal behavior during hospitalization. A marked improvement was achieved when a combination treatment of clozapine (400 mg daily) and maprotiline (ISO mg daily) was commenced.
No associated side ellects or adverse events were observed. Attempts to significantly decrease the dosage of either clozapine or maprotiline were Followed by repeated relapse of the depremive symptomatology.