Publication at Second Faculty of Medicine |
2000
Abstract
Lidocaine clearance test may reflect the integrity of various oxidative pathways of hepatocytes. Lidocaine isa highly sensitive indicator of hepatic dysfunction.
This test is applicable to assessment of stage and prognosis ofthe liver disease, to timing of the liver transplantation, and to assessment of the pretransplant prognosis in the end-stageof chronic liver disease. Formation of the major lidocain metabolite monoethylglycinexylidide (MRGX) depends onthe hepatic cytochrome P-450 activity and on the liver blood flow.