Ultrastructure of the Tracheal Epithelium in Rabbits (Oryctolagus cuniculus var. edulis) after Intratracheal Administration of Two Iodinated Contrast Agents
Abstract
The ultrastructure of the tracheal epithelium was studied after intratracheal administration of two contrast agents - iopamidol (Iopamiro) and iohexol (Omnipaque)- used in clinical practice for tracheobronchography. The injury of the tracheal epithelium due to the iopamidol and iohexol administration was classified as mild and moderate, respectively.
In both experimental groups bacteria and inspissated mucus were revealed in the area of the impaired ciliary border as morphological signs of the impairment of the self-cleaning ability. The uneven distribution of the contrast media particles were encountered in the airways.
In the areas of its highest accumulation the disturbances of the cell membranes and the impairment of the inner structure of the cilia were recorded.