Final Height of Patients Following Long-Term Treatment for the Idiopathic Growth Hormone Deficiency. (The Czech Register 1991-1998)
Abstract
Background. Final height was evaluated in patients from the Czech Register with idiopathic growth hormone deficiency treated with GH.
Methods and Results. 23 patients had the isolated growth hormone deficiency (group 1), and 37 suffered from multiple pituitary hormones deficiencies (group 2). The patients from group 1 and 2 were given growth hormone for 6.7+-2.2 years and 9.6+-3.0 years, respectively.
The patients with isolated growth hormone deficiency reached final height -1.4+-1.3 SDS, those with multiple hormone deficiencies were taller (-0.7+-1.5 SDS). The height gain equalled +2.5+-0.6 SDS and +3.4+-1.1 SDS in group 1 and 2, respectively. 70% of the patients in group 1 and 93% of group 2 reached final heights within the target limits (+- 2 SDS).
Conclusion. The final height positively correlated with the target height (mid-parental height) and height at the onset of puberty (group 1 and 2).
There was a negative correlation between the final height and the chronological age at the beginning of growth hormone therapy in group 1.