Abstract
Information theory is the conceptual framework for understanding the psychopathology and mechanisms of psychiatric treatment. Schizophrenia as the disorder of information processing should be the reslt of the decrease connectivity of pyramidal neurons.
Antipsychotic drugs modulate information processing by the regulation of domaninergic activity and this way they optimize the signal/noise ratio. By this mechanism the antipsychotics compensates the deficit of synaptic connectivity.
Second generation antipsychotics in comparison with classical ones not only block the D2 receptors but also due to the 5-HT2 antagonism also increase the dopamine in prefrontal kortex. The increased dopamine in prefrontal kortex leads to the amelioration of negative symptoms and cognitive dysfunction.