Abstract
Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride.
Methodology: Plasma prolactin levels were measured in 5 males and 5 females with depressive symptoms who were treated with 50 mg of amisulpride per day as an augmentation to antidepressants (n=5), benzodiazepine anxiolytics (n=8) or in monotherapy (n=1). Six of these patients were assessed prior to onset of amisulpride treatment and after 10 days of amisulpride use.
Four patients had been using amisulpride for more than a month. Results: There was a significant increase of prolactin levels from mean 16-6 ng/ml to 113-65 ng/ml (median 14.5 ng/ml to median 92 ng/ml; Wilcoxon matched pair test, p=0.027).
All patients had hyperprolactinemia (30-200 ng/ml). The prolactinaemia was significantly higher in females (mean 160-50 ng/ml; median 198 ng/ml) than in males (mean 48-12 ng/ml; median 48 ng/ml; Mann-Whitney U test, p=0.041).
Conclusion: Even low doses of amisulpride used as an augmentation to antidepressant treatment, benzodiazepines or in monotherapy seem to be associated with hyperprolactinemia. The co-medication of antidepressants and benzodiazepines can potentially increase intensity of prolactinemia.