Abstract
The authors describe the cognitive effects of antidepressants and their influence on the state of alertness and memory. Sertraline and milnacipram are newer antidepressants that have not been shown to have a negative effect on cognitive function in healthy subjects.
In depressive patients maintain certain antidepressants (eg trazodone or dosulepin) for the control of vigilance. Viloxazine and maprotiline have a negative effect either on alert or on the visual and verbal memory.
Sertraline improves attention and verbal learning in depressive patients over 60 years, significantly more than nortriptyline. Venlafaxine and moclobemide improved vigilance in depressive patients.
Moclobemide, fluoxetine, citalopram and trazodone improve memory function in depressive patients. And long-term use of tricyclic antidepressants (median 11.5 years), which have the highest anticholinergic side effects and could be assumed they farmakogenně induced dementogenní effect did not result in a higher decline in MMSE compared with probands who did not use tricyclic antidepressants.
Elektrokonvulze (ECT) is still the most effective method of treatment of depressive disorders, however, lead to intermitentnímu deterioration of memory functions. Disorders of memory after ECT continuously improve after 3-6 months after completion of ECT is no longer demonstrable deficit.
Repeated application of low-frequency and high frequency repetitive transcranial magnetic stimulation to the prefrontal cortex of depressed patients did not result in impairment of cognitive functions and some cognitive functions are improved.