Abstract
Within a last decade, rTMS has been used for the treatment of depression, mania, and schizophrenia. Antidepressant response has been reportedin open and double-blind, sham-controlled studies.
Less is known about rTMS efficacy in the obsessive compulsive disorder. The aim of the randomized, double-blind, sham controlled study was to compare the efficacy of the 10 sessions rTMS with sham rTMS in serotonin reuptake inhibitor resistant OCD patient.
Thirty seven patients were randomly assigned to either active rTMS or to sham. Active rTMS with the frequency of 1 Hz at 110 % of motor threshold was administered over the left dorso-lateral prefrontal cortex.
The same time schedule has been used for the sham administration. Thirty four patients finished the study, three patients' dropped out at the beginning.
Psychopathology was assessed by CGI, HAMA, Y-BOCS and BAI before the treatment, immediately after the experimental treatment, and 2 weeks after by an independent reviewer. Both groups improved during the study period but the treatment effect did not differ between them in any of the instruments.