Abstract
Proteins released to circulation from affected tissues during primary or secondary trauma brain injury might be used as serum markers of glial or ganglial cells damane (neuron specific enolasis and S 100B protein). Other markers of trauma can be proved as relatively specific of difuse axonal injury by immunohistochemical detection (amyloid prokursor protein, neuron specific enolasis, glial fibrila acidit protein and superficial antigen receptor CD 68).
Some markers are dissociated with blood barrier damane (matrix metaloproteinases (MMP-2, MMP-9) and synthase of nitric oxide (iNOS)). We aimed in our short communication on biomechanics of developed of trauma, primary or secondary kinds of trauma brain injury and use of trauma brain injury markers for clinical diagnostics and management of patiens