Among the morphological changes of cervical columnar epithelium, the most serious is cervical glandular intraepithelial neoplasia (CGIN). In this classification it is not necessary to distinguish between CGIN and adenocarcinoma in situ.
Microinvasive adenocarcinoma is determined by stromal invasion no greater than 5.0 mm in depth with a horizontal spread 7.0 mm or less. The most frequent cervical adenocarcinoma is mucinous carcinoma, other adenocarcinomas are rare.