Abstract
Anaphylaxis is defined as severe, acute allergic reaction involving several organ systems. The principal effector cells are mastocytes; the major activations pathways through IgE, probably also complement receptors and other pathways are involved.
Mast cells are localized around the body with different patterns of behavior. Histamine and tryptase are released after mast cell activation, tryptase seems to be a valuable diagnostic marker for anaphylaxis.
The organism has defense compensatory mechanisms which cans be disrupted in some particular situations