Publication at Third Faculty of Medicine |
2008
Abstract
In this study, we analyzed changes in the expression of these markers and proinflammatory enzymes cyclooxygenae 2 (COX-2) and inducible nitric oxide synthase (iNOS) in samples obtained from pacients with ulcerative colitis-associated neoplastic epithelial changes and in samples of sporadic colon cancer.Compared to mucosa of UC patients without dysplasia the UC-associated neoplasia expressed significantly elevated transcripts of survivin, c-MYB, TcF-4, COX-2 and iNOS, whereas hTERT and ILK expression was not significantly elevated. In contrast, the specimens of CRC showed upregulated expression of not only survivin, c-MYB, Tcf-4, COX-2 and iNOS but also hTERT.