Abstract
The current classification systems in psychiatry increased the reliability of diagnostic categories. However, the neurobiological validity of these categories is less substantial.
Moreover, the classification based on arbitrary operational criteria would substantially decrease the power and impact of genetic, physiological and neuroimaging findings. The reasons embody in history of psychiatric classifications.
The crisis of psychiatric nosology would be solved by the validity searching in the bottom-up direction. In the basic step, the sets of elementary signs (semantems) from the field of descriptive psychopathology (closed system) and neurobiology (open system) would be collected.
The signs would be clustered (syntax) according the parameters of co-occurrence, causality and temporal sequentiality. This step would be followed by the reduction of components according to the functional interactions, formation of working diagnoses and their testing according to postulated rules for reeditions of diagnostic manuals.