Publication at Third Faculty of Medicine |
2010
Abstract
Aim of the study: To establish endothelial activation markers which could uncover endothelial damage during physiological pregnancy. We examined 403 pregnant women with a physiological pregnancy.
Venous blood samples were collected from the women at the beginning of the pregnancy, a second sample was collected in the interval 24-28 weeks gestation. Parameters were examined using methods: t-PA - ELISA, PAI-1 - ELISA, vWF Ag - EIA ePCR - ELISA, MMP-2,9 - ELISA with fluorogenic detection, TIMP-2 - ELISA, endothelial microparticles - flow cytometry.