Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls
Abstract
Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF.
Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. 10 nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution.
Outgoing dialysate glycerol concentration (DGC) was measured as an index of lipolysis. BNP(1-32) exerts strong lipolytic effects in humans.
Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) is not attenuated in HF, possibly reflecting a deficiency of endogenous bioactive BNP. Lipolytic effects of BNP can contribute to excessive fatty acid mobilization in advanced HF.