Interspecies differences in metabolism of carcinogenic azodye 1-phenylazo-2-hydroxynaphthalene (Sudan I) in vitro

Abstract

Sudan I is oxidized by hepatic microsomes from rats, rabbits, minipigs and human. Our results are discussed because of eventual risk to human.

Keywords

• Sudan I
• 1-phenylazo-2-hydroxynaphthalene
• carcinogens
• cytochromes P450
• DNA adducts
• rats
• rabbits
• human
• minipigs