Ellipticine and Ellipticinium-human serum albumin (Elli-HSA) conjugate are cytotoxic and form covalent DNA adducts detected by 32P-postlabelling.

Abstract

A new mechasnism of action of anticancer drug ellipticine and its conjugate with human serum albumin is described. This mechanism is a formation of covalent DNA adducts in vitro and in cells in culture.