Fosfonodipeptidy, syntéza metodou HOBt/DCC, hmotnostní spektra chráněných a 1H NMR spektra nechráněných fosfonodipeptidů

Abstrakt

Phosphonodipeptides containing aminomethylphosphonic and 1-aminoethylphosphonic acids were synthesized by the active ester method using N-hydroxybenztriazole and DCC. Fragmentation in electron ionization mass spectra (EI/MS) of protected phosphonodipeptides has been proposed.

Results from (1)H NMR have shown slightly larger magnetic nonequivalence of -CH2- protons and larger differences in NMR parameters between diastereoisomers than in common dipeptides.

Klíčová slova

• phosphonodipeptides
• hypophosphite addition
• tritylimines
• mass spectra
• 1H NMR spectra