Phosphonodipeptides. Synthesis by HOBt/DCC Method, Mass Spectra of the Protected and 1H NMR of the Unprotected Phosphonodipeptides

Abstract

Phosphonodipeptides containing aminomethylphosphonic and 1-aminoethylphosphonic acids were synthesized by the active ester method using N-hydroxybenztriazole and DCC. Fragmentation in electron ionization mass spectra (EI/MS) of protected phosphonodipeptides has been proposed.

Results from (1)H NMR have shown slightly larger magnetic nonequivalence of -CH2- protons and larger differences in NMR parameters between diastereoisomers than in common dipeptides.

Keywords

• phosphonodipeptides
• hypophosphite addition
• tritylimines
• mass spectra
• 1H NMR spectra