Acute anicteric hepatitis with intrahepatic cholestasis induced by prajmalium bitartarate (Neo-Gilurytman) administration
1994
Abstract
The authors draw attention to a serious drug response to the derivative of the alkaloid ajmaline prajmalium (Neo-Gilurytmal, Giulini-GFR) which causes impairment of liver functions of various grades as a result of intrahepatic cholestasis. They draw attention to the necessity of a careful pharmacological case-history, evaluation of the premorbid stage, in particular former liver disease or contemporary administration of drugs which burden liver function (hormonal contraceptives, non-steroid antirheumatic drugs).
It is essential to follow-up liver functions by laboratory tests already at the onset of treatment with Neo-Gilurytmal.