Metabolic pathways of flobufen - a new antirheumatic and antiarthritic drug. Interspecies comparison

Abstract

Metabolic transformation of flobufen [4-(2´, 4´-difluorobiphenyl-4-yl)-4-oxo-2-methylbutanoic acid], a non-steroid antiinflammatory agent to its major metabolites, were studied in vitro using the different biological models and species