Contribution of aldo-keto reductases to the metabolism of the novel anticancer drug oracin in man

Abstrakt

Contribution of human liver cytosolic reductases from AKR1C family is desribed to be significant in the metabolism of anti-cancer drug oracin; exclusive stereospecificity of AKR1C2 and AKR1C4 and very high stereospecificity for AKR1C1 were found