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HPLC analysis of amlodipine and plasma protein binding of its enentiomers

Publication at Faculty of Pharmacy in Hradec Králové |
2004

Abstract

Protein binding of amlodipine enantiomers in human and rat plasma was studied by equilibrium dialysis and achiral HPLC. Binding of amlodipine to plasma proteins of both specie was relatively high (more than 92%)