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Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats

Publication at Central Library of Charles University, Faculty of Pharmacy in Hradec Králové |
2009

Abstract

The aim of this study was to evaluate changes in methotrexate, an important anticancer and immunosuppressive agent, biliary and renal excretion during either intrahepatic or obstructive cholestasis in rats.