Neuroregeneration after spinal cord injury and in amyotrophic lateral sclerosis - possibilities for stem cell therapy

Abstract

Mesenchymal stromal cells are multipotent cells that currently are one of the best candidates for the treatment of neurological disorders such as spinal cord injury and amyotrophic lateral sclerosis. The results described in the thesis show that the transplantation of MSC, isolated either from fat tissue or bone marrow, is a safe and effective procedure that enhances regeneration/neuroprotection after SCI and in ALS.

A combination of MSC with chaseABC in the treatment of SCI could facilitate regeneration and thus could be an attractive approach for translational bench-to-bedside studies.