Abstract
Pancreatic carcinoma is one of the tumours with the worst prognosis. Even today its risk factors are not clear.
Since the Czech Republic is one of the countries with the highest occurrence of this disorder in the world, a case-control study of this tumour was initiated by the InternationalAgency for Research on Cancer, originally only in Czech Republic, with possible enlargement to other centres. The epidemiological part of the study gave no valid explanation for the relatively high occurrence of pancreatic tumours in Central Europe.
First genetic analyses have produced interesting results, but a larger set of samples is necessary to confirm them.