Abstract
Overt diabetic nephropathy develops primarily as a result of hyperglycaemia in the genetic predisposition terrain. Itsprogression to renal failure is primarily determined by the blood pressure height.
Effective treatment lowers the rates of renalfunction loss to half. First choice drug are AT1receptor blockers and ACE inhibitors.
To lower the incidence of renal failure orovert diabetic nephropathy, there is necessary an early diagnostics of incipient diabetic nephropathy (microalbuminuria). In upto 10% of patients with diabetes and proteinuria the cause of proteinuria is different from diabetic nephropathy.