Abstract
The goal of type 2 diabetes mellitus treatment is still close compensation. Pharmacotherapy should be initiated immediately after diagnosis.
The basis of treatment is metformin, in case of lack of effect combination with other oral antidiabetics (PAD), eventually with insulin, is needed. Individual PAD should be selected according to the individual patient profile.
It is necessary to propose a therapy so that the risk of hypoglycaemia is reduced as much as possible. Selection of the appropriate treatment is based on knowledge of fasting glycaemia and postprandial glycaemia, respectively their mutual ratio.