Abstract
Diabetes mellitus type 2 is a genetically determined disease. Currently, prediction of diabetes based on the identification of risk genes is not sufficiently contributive with respect to polygenic inheritance.
The time when diabetes manifests or whether it manifests at all is related to regimen, the accumulation of body fat, physical activity and, as becomes evident, also to the manner of treatment of comorbidities (hypertension, hyperlipoproteinemia). In persons who are at risk with respect to diabetes manifestation and who significantly change their regimen, alter dietetic habits and incorporate physical activity in their everyday program (often also reducing their body weight), there is much less probability that diabetes will develop.
By combining certain antidiabetic drugs and altering regimen, even better results can be achieved.