Muscle atrophy associated with impaired exercise tolerance is frequently observed in patients with chronic obstructive pulmonary disease and was considered as a benign complication without exploring the cause. Recently, the origin of this defect has been recognised and the possibility of limitation and reparation are found in complex pulmonary rehabilitation programs.
In this way, the enzyme capacity of large extremity muscle groups can be increased and the limited oxygen uptake better utilized. Rehabilitation programs should be performed for at least 8 weeks in order to achieve a significantly increased quality of live.