Treatment of type 2 diabetes mellitus with oral antidiabetics. Part 5 - Glinids (meglitinides), acarbose, incretins
2009
Abstract
Glinides are derivatives of meglitinide and by their mechanism of action belong to the group of insulin secretagogues. They act similarly to sulphonylurea antidiabetics, but do not bind to sulphonylurea (SU) receptors and are therefore referred to as non-sulphonylurea insulin secretagogues.
The administration of glinides is based on their mechanism of action: they can be administered just before a meal, and it is recommended to omit the preprandial dose of glinides if you miss a meal. Glinides can be given as monotherapy or combined with treatment with insulin sensitisers (metformin and glitazones).
A favorable combination of glinides (during the day) with insulin (at night) has also been documented in the literature.