Abstract
Obesity contributes significantly to the emergence of insulin resistance and 2 diabetes Long-term positive energy balance results in patients with obesity to the progressive exhaustion of the capacity of adipose tissue to store lipids and the lipids (particularly triglycerides, and their metabolites) are stored in other tissues and organs. Typically, ectopic lipid storage in liver, muscle and pancreatic tissue.
Ectopic stored lipids leads postreceptorovou signal interfering with the cascade of insulin resistance in liver and muscle tissue, or a failure of insulin secretion in the pancreas.