S-100 Protein and Neuron Specific Enolasis in the Clinical Diagnostics of Brain Impairment

Abstract

Within a group of 28 patients with clinically manifested CNS affection, the concentration of S-100 protein and neuron specific enolasis in the serum and in the cerebrospinal fluid was monitored using commercial sets, The concentrations of neuron specific enolasis in the serum corresponded to normal serum values, in the cerebrospinal fluid a pathologically increased value was identified only once. With the S-100 protein, abnormally increased values were recorded three times in the serum while in the cerebrospinal fluid all the measured values except for two were pathologically increased.

The correlation of levels of the examined neuropeptides with the clinical condition of patients with nerve lesion has not been proved.

Keywords

• neuron-specific enolase
• S-100 protein
• myelin basic-protein
• cerebrospinal-fluid
• serum-levels
• acidic protein
• s100b
• injury
• neurofilament
• sclerosis
• dynamics
• disease