Risk factor analysis for early mortality and morbidity following pneumonectomy for non-small cell lung cancer
Abstract
Objectives: The purpose of this report is to analyze factors affecting morbidity and mortality following pneumonectomy for non-small cell lung cancer (NSCLC). Methods: We reviewed our institutional experience with all consecutive patients undergoing pneumonectomy for NSCLC from 1998 to 2010.
Patients were analyzed with regard to hospital mortality and morbidity and long-term outcome. Results: There were 310 patients following pneumonectomy.
Overall 30-day mortality rate was 5.5%. Chronic obstructive pulmonary disease, induction therapy, smoking habits and obesity had no statistical influence on short-term outcome.
Coronary artery disease and respiratory failure were identified as risk factors for increased 30-day mortality (p<0.01). Right pneumonectomy and presence of respiratory failure with mechanical ventilation increases the incidence of bronchopleural fistula (p<0.01).
Conclusions: Patients with right pneumonectomies are at increased risk. Coronary artery disease and respiratory failure adversely affect morbidity and mortality after this procedure.