Publication at Second Faculty of Medicine |
2010
Abstract
Type 1 diabetes is a serious disease from a social as well as an economic point of view. The underlying mechanism of the disease is an autoimmune destructive insulitis with the crucial role of autoreactive T cells which are Th1 polarised.
Also other abnormalities such as differences in T regulatory cells or a difference in antigen processing and presentation may contribute to the disease onset as well. In this publication current knowledge on complex type 1 diabetes immunopathology is introduced and this section is followed by an analysis of the most important immunointervention studies which have been conducted in relationship to this disease.