Abstract
Allergen-specific immunotherapy is the curative method of treatment for allergic diseases and it has been used for 100 years. New researches in immune intervention include targeting of molecular mechanisms of allergen specific tolerance.
The mechanisms of action of allergen-specific immunotherapy include modulation of T and B cell responses and related antibody isotypes especially IgE and IgG4. It has an influence on migration of eosinophils, basophils and mast cells to tissues as well as release of their mediators.
Regulatory T (Treg) cells have been indentified as key regulators of immunologic processes in peripheral tolerance to allergens. Skewing of allergen-specific effector T cells to a regulatory phenotype apperas as a key event in the development of healthy immune response to allergens.
If the mechanisms of action of SIT include such changes, it is not reason of increase the risk of autoimmune disorders.