Psoriasis - immunopathogenesis and modulation of immunopathological reaction by biological therapy

Abstract

Psoriasis is a chronic systemic immunopathological disease caused by disturbances in innate immunity, especially dendritic cells which are stimulating T cells which further differentiate into immunoregulatory subsets. The therapeutical application of biological therapy is discussed.

Keywords

• psoriasis
• pathogenesis
• dendritic cells
• alarmins
• T cell subsets
• biological therapy