Abstract
Increasing prevalence obesity represents one of the most significant problems of current medicine. Tight interconnestion of obesity with insulin resistance, type 2 diabetes, arterial hypertension, dyslipidemia and many other pathologies commonly referred to as metabolic syndrome markedly increases cardiovascular risk of obese patients and their cardiovascular risk of obese patients and their cardiovascular morbidity and mortality.
During the last twenty years, important active involvement of adipose tissue in metabolic regulations and its role in the etiopathogenesis of almost all metabolic complications of obesity has been discovered and intensively studied. In this paper we provide an overview of these mechanisms and discuss possible perspectives of their utilization in the prevention and treatment of obesity and its related metabolic diseases.